The Complicated Biology of Breast Cancer - 977 Words

After hearing your concerns about breast cancer, I decided to use my knowledge and research to guide you through the more complicated biological side of breast cancer. Within this letter I hope to better your understanding of cancer, especially breast cancer. Its the causes, pros and cons of genetic testing, and my recommendations for you and your daughters. I will also discuss the controversial decision of actress Angelina Jolie. Cancer is a term used to describe diseases that include abnormal cell division, which means that cells don’t die when they’re programmed to and replicate without control. In a healthy body, the creation, growth, and death of a cell is controlled through the body’s natural processes, called apoptosis. When these systems are unable to maintain control, cancer occurs and there is more cell replication than death (Phelan). The different types of cancer are usually referred to by the type of organ where cells have begun to replicate without control. For example, breast cancer is the type of cancer that affects cells within the breast tissue (The National Cancer Institute). Breast cancer can be inherited or occur by chance within cells. Within cells there are genes, pieces of DNA that hold genetic information and instructions for how to make the proteins the body needs to function correctly. Genes have two main roles when it comes to cancer. Some, genes, oncogenes, cause cancer, while other genes, tumor suppressors, are supposed to stop cancer fromShow MoreRelated Soy Protein: Can It Really Prevent Cancer? Essay974 Words   |  4 PagesSoy Protein: Can It Really Prevent Cancer? Society possesses a natural fear of the disease cancer. Even though this term is common, uncertainty surrounds its meaning. What exactly is cancer? A simple definition for a complicated disease is this: abnormal cell growth. Cancer can develop in just about any part of the body, and as abnormal cells grow, they crowd and destroy healthy tissue. This disease is not infectious, for if it were, a vaccination would have probably been developedRead MoreCancer Literature Review1462 Words   |  6 Pagesis based on the Genome-wide association studies of cancer, or GWAS. GWAS is an approach to research the genetic basis of different diseases. For example, with oncology, GWAS was performed and able to identify approximately 450 genetic variants that are related to the risks, as well as provided proof of polygenic susceptibility. This review targeted on the functional basis and gene structure of cancer susceptibility. Regarding cancer, there’s a pattern of relative risk or RR, that’s highRead MoreD1029 Words   |  5 Pagesexpression of more than one genes in a network of differential complicated signaling pathways, consisting of many physical and functional interactions.Unlike the stable genome structure, the dynamic represents a major challenge for quantitative mapping of protein interactions .The intracellular signal transduction involves the 2 complicated working networks of interacting cytoplasmic signaling pathways and an even more complicated circuit, such as functional interactions rather than contact betweenRead MoreNew Drugs For Breast Cancer Treatment Essay1382 Words   |  6 Pageswithout affecting host body cells. Cancer chemotherapeutic agents New Drugs for Breast Cancer Treatment: 1. Herceptin: ïÆ' ¼ Type of drug: Monoclonal antibody A class of drugs developed to work alone or together with chemotherapy to seek out and attack specific cancer cells. ïÆ' ¼ Mechanism: Herceptin attaches itself to a protein called HER2 that is found on the surface of 20 to 25 percent of breast cancers. HER2 stimulates cell growth and prevents breast cancer cell death. When Herceptin binds toRead MoreThe Ins and Outs of Cancer Essay634 Words   |  3 PagesThe Ins and Outs of Cancer Cancer has affected the lives of each and every one of us alive today. Many people have know someone with cancer, yet even those who havent have been bombarded with constant reminders of its terrible threat. Although cancer is often referred to as a single condition, it actually consists of more than 100 different diseases, all characterized by the uncontrolled growth, reproduction, and spread of abnormal body cells. All of these diseases are individually uniqueRead MoreAn Expert And A Disciple For An Extended Period1663 Words   |  7 Pagesis a branch of science that deals with the physical world including but not limited to biology and is one area of knowledge that causes disagreements between experts. Therefore, a situation dealing with the biological makeup of a woman and the ways that a breast functions falls under the natural science area of knowledge. There are vast amounts of information from different sources about many aspects of biology which is accessible to any expe rt in the medical field. Therefore, an understanding ofRead MoreCancer : Cancer And Cancer1673 Words   |  7 PagesCancer Cancer is one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases in 2012.2 The amount of new cases is expected to rise by about 70% over the next 2 decades. Cancer which causes nearly 1 in 6 deaths, is the second leading cause of death globally, and was responsible for 8.8 million deaths in 2015. Approximately 70% of deaths from cancer occur in low- and middle-income countries. In 2012 about 14.1 million new cases of cancer occurred globallyRead MoreThe Most Vital Functions Of The Nervous System1233 Words   |  5 Pagesexpensive public health condition with annual cost to society exceeding that of combined costs of diabetes, cancer, and heart diseases. Then, we have set of diseases that follow chronic pain. This includes, but not limited to, depression, stress related disorders and diseases caused due to immobility. Regrettably, chronic is usually co-morbid with other conditions like diabetes and cancer, and its incidence increases w ith age. Hence, if left unchecked, all we can expect is a steady rise in its prevalenceRead MoreDark Life by Ray Taylor1704 Words   |  7 PagesThis alone questions everything the standard definition of life states. However, one may question, â€Å"what qualifies Taylor to do such a thing?† Michael Taylor is a writer. One may now declare that a writer has no knowledge of microbiology, or any biology for that matter, and is in no way shape or form qualified to write a book about said topics. One would be wrong. Taylor has written for the National Geographic Traveler and the website of the Discovery Channel. He has also consulted on documentariesRead MoreAnalysis Of The Film Forks Over Knives880 Words   |  4 Pagesdiabetes type two are now commonly seen in children. One reason for this being the fast paced life of Americans, developed after WWII, produced convenience food, rich with processed sugars and fried meat. What was supposed to make life simpler soon complicated it with unimaginable side effects. The sicker the U.S becomes the more pills are prescribed. Unfortunately, none of these treatments are quite as effective as hoped to be. However, there is one solution that may be able to reduce health diseases;

Supporting Gay Marriage Supporting Lesbian Marriage

Supporting Gay Marriage Supporting Gay Marriage Lindsey and Beth, a lesbian couple, have been living together for eleven years. Lindsey conceived two children from a sperm donor. Together, Lindsey and Beth turned their house into a loving home for their two children. One day, on the way home from the grocery store, Lindsey was killed in a tragic car accident. Before Beth could even grasp the situation, the children that she helped raise from birth had been taken away and placed into the care of Lindsey s parents, who never were a part of their lives because they did not accept Lindsey s homosexuality. In addition, the house that Beth and Lindsey lived in for eleven years was taken away from Beth. How did this happen to Beth? Well, if Lindsey and Beth could have been legally married like all heterosexual couples, Beth would have had custody of the children and would have kept the house. They would have received 1,049 protections, benefits and responsibilities that are extended to married couples under federal law (HRC). Lindsey and Beth are one example of same sex couples that live in 99.3 percent of all counties in the United States (HRC). It is estimated that 10 percent or 25 million people in the United States are homosexuals, and by law they do not have the rights that married heterosexuals enjoy. American voters have the power to change the law and prevent the sad story that Beth had to live, by voting yes on referendums in support of gay marriage, and no onShow MoreRelatedSupporting Gay Marriage : Lesbian Marriage2225 Words   |  9 PagesSupporting Gay Marriage Lindsy and Beth, lesbian couple, have been living together for eleven years. Lindsy conceived two children from a sperm donor. Together, Lindsy and Beth turned their house into a loving home for their two children. One day, on the way home from the grocery store, Lindsy was killed in a tragic car accident. Before Beth could even grasp the situation, the children that she helped raise from birth had been taken away and placed into the care of Lindsy s parents, who never wereRead MoreArguments Against Same Sex Marriage704 Words   |  3 PagesSame-sex marriage is a huge controversial issue still being debated in the world today. Many people believe that same-sex marriage is not justifiable but then many others believe that there is no problem with this circumstance. I believe that homosexuals and lesbians should be permitted to marry if they choose to. After researching this issue for two-weeks, I came across four different people, two against and two for the issue on same-sex marriag e. They all have strong opinions and arguments on thisRead MoreLegalizing The Same Sex Marriage1118 Words   |  5 Pageslegalizing the homosexual marriage. The social movement for legalizing the same-sex marriage in U.S. started in the 1970s. People who support homosexual marriage carried on their campaign arguing that banning gay marriage is a ‘discrimination’, which is similar to the prohibition of racial intermarriage that existed in past. Since lots of homosexuals all around the world insist their basic rights of marriage, there are plenty of serious debates going on about their marriage. Denmark was the first countryRead MoreMedia Analysis of a Current Controversial Issue875 Words   |  4 Pagesmedia. Some nations like the US have legalized homosexuality and this is why there has been uproar after the president of Uganda signed a bill in parliament outlawing homosexuality. The media has always been blamed of being bias while reporting on gay marriages and homos exuality. The homosexuality group is a minority group that is always viewed very different by the society. Many forms of media are used to address these topic namely; the social media, television, newspapers, and magazines. The socialRead MoreSame Sex Marriage Affirmative Side1556 Words   |  7 PagesThat Same Sex Marriage Should be Legalized in the Philippines (Positive) Premises 1.) To exercise freedom of choice. 2.) To control population. 3.) To have an opportunity to adopt children from orphanage. 4.) To practice human rights. 5.) To prevent HIV disease. INTRODUCTION Same sex marriage is known as a marriage between two persons of the same biological sex or gender . It is one of the most controversial yet sensitive topics that have been discuss around the world. Politicians are havingRead MoreEssay about Gay And Lesbians Marriage970 Words   |  4 Pagesï » ¿Gay and lesbians Marriage People question themselves all the time, what is love? There are numerous definitions of what love is but love in my opinion is when two people different feel connected doesn’t matter what race, nationality, or gender. Love lies within every human. Every human being should have the full right to love whoever they want. There should not be any discrimination against love. Love has many different form, some that people will never understand such as gay and lesbian love.Read MoreShould Gay Marriage Be Legal? Essay911 Words   |  4 PagesShould gay marriage be legal? Gay marriage should be legal because as woman and man, all individuals have the same right in society; because same-sex couples can constitute a good based family; because it is just a way to make official a common union nowadays, even with the religious issue; because it is not related to polygamy; and because love matters and it does not differ in nature according to the sex of its object or the person who experiences it. The first reason why same sex marriageRead MoreEssay Gay Marriage Should Be Legal889 Words   |  4 PagesOn June 26, 2015, the US Supreme Court ruled that the US Constitution guarantees the right for same-sex couples to marry. Should gay marriages really be allowed? Has the Supreme Court ruled in error? Gay marriage should be legal because all individuals have the same right in society; because same-sex couples can constitute a good based family; because it is just a way to make official a common union nowadays, even with the religious issue; because it is not related to polygamy; and because loveRead MoreMarriage Should Be A Privilege For All962 Words   |  4 PagesAllanna Iverson Mrs. Trandall LA10 1 March 2016 Marriage should be a privilege for all Most people believe that they deserve the rights they are granted by the government. An upstanding citizen who pays their taxes, serves their community and abides by the law should be afforded the rights of an American. However, not all citizens are afforded equal rights. In the past, there has been many examples of discrimination. Women not being allowed to vote, blacks being segregated, and Japanese-AmericansRead MoreThe Fundamental Right to Same-Sex Marriage Essay718 Words   |  3 PagesThe legalization of same-sex marriage has been a controversial issue for years. Arguments have risen between political and religious point of views over the controversial topic. While many believe it is morally and ethically wrong, there are others who believe it is emotionally and socially acceptable. More than half the country legally denies the right to marry between lesbian or gay couples. When denying same-sex couples to marry, the government is degrading the rights of citizens and is encouraging

Corporation Rules and Regulations free essay sample

The group had been liable for 70% of Australian asbestos consumption. However, in February 2007, ASIC had started to impose civil proceedings against James Hardie, the directors and the officers, as ASIC alleged that JHIL and both executive and non-executive had breached their statutory duty. This short research report had outlined the role of ASIC and various penalty that ASIC can impose under Corporation Act 2001. Besides that, we will also discuss the position that ASIC had held from 2004 until current date in relation to the directors of Hardie group. At last, I had provided a summary of the ASIC’s media release that had been established on 13 May 2011, and indentified the element that ASIC is hoping the High Court to uphold. The Role of ASIC: The Australian Security and Investment Commission (ASIC) is a commonwealth statutory corporation that set up by Australian Securities and Investments Commission Act, and it is a regulator which in charge of monitoring the Australia’s Corporation, products, markets and financial services (Lipton, Herzberg and Welsh 2012, p. 736). On the other hand, ASIC is also a commonwealth authority that is responsible for governing the Corporation Act. ASIC Act provided that ASIC owned such powers and function that endowed by the corporation legislation to ASIC. Thus, what exactly is the corporation legislation means? Under Section 5(1), they had interpreted the term ‘corporation legislation’ to mean the ASIC Act and the Corporation Act (Baxt, Finnane and Harris 2012). Besides that, ASIC also owned the power to initiate prosecution for criminal offences or apply for civil penalty orders if they believed that there’s a contravention of the law. ASIC is also able to ban a director from managing a company for a certain period if they contravened their general duties. For instance, in the case of ASIC v Stephen William Vizard [2005], the court held that as a director of Telstra, Mr. Vizard has contravened the Corporation Act: Section 183, the duty of director to use the information in an improper purpose, and gain advantage for himself, thus, the court order pecuniary penalties and a disqualification order against Mr. Vizard (Price Waterhouse Coopers 2012). As a result of that, ASIC actually played a significant role in relation to initiate prosecution against companies directors for misconduct in order to ensure corporation and those related parties are complied with the corporation legislation. Now, let us look at the duties of a corporation’s directors under Corporation Act and what penalty can ASIC can imposed if the directors do not comply with the Corporation Act. The duties of a company’s director: The term ‘director’ is a person who is appointed to manage control or govern the affairs of a corporation. Under Section 9 definitions, the term directors extend to a person who is not formally appointed as a director, but they act as a director or whose instruction or whishes are followed customarily (Baxt, Finnane and Harris 2012). In chapter 2D. 1 of the Corporation Act, from Section 180 until Section 184, it dedicated that the principle duties of a director. They can be listed as followed: †¢Section 180 stated that a director or other officer of a corporation must exercise their power and discharge the duties in a manner with care and diligence (Mclnnes Wilson Lawyers 2011). Section 181 declared that, a director should exercise their power and discharge their duties in good faith where it’s in the best interest of the corporation and for a proper purpose (Mclnnes Wilson Lawyers 2011). †¢Section 182 stated that, a director must not improperly use their position to obtain an advantage for themselves or other or cause lesion to the company. (Armstrong Lawyers 2007). Having understood the general duties of a company’s director, we can now look at the penalties that ASIC could impose if the directors had breach their duty or do not comply with the Corporation Act 2001. The penalties: As we mentioned before, the Australian Securities and Investment (ASIC) is a national body that’s responsible to govern the corporation legislation and securities regulation in Australia. ASIC obtained the power to investigate potential contravention of the corporation law and significant penalties can be imposed on the directors who had failed to perform their duties. The section of the Corporation Act attracting civil penalties under Section 1317J (1), ASIC can apply to the court for a: †¢Ã¢â‚¬ËœDeclaration of contravention’ †¢Ã¢â‚¬ËœPecuniary penalties ‘ †¢Ã¢â‚¬ËœCompensation order’ (Baxt, Finnane and Harris 2012) 1)Pecuniary penalty order: The court may order a pecuniary penalty of up to $200,000 to a director who breaches his duty under Corporation Act. Once the declaration of a contravention by the person had been made (Section 1317E), and the contravention is a corporation penalty (Price Waterhouse Coopers 2012). (2)Compensation order: Under Section 1317H, the court may order a person to compensate the company where loss is suffered because the person had contravened a corporation civil penalty provision (Price Waterhouse Coopers 2012). (3)Disqualification from managing a company: The Corporation Act Section 206C conferred ASIC the power to disqualify the directors from managing a company for a certain periods of time due to the contravention of their general duties (Price Waterhouse Coopers 2012). This concept can be illustrated by the following case: ASIC v Vines [2006], it had been found that Mr. Vines had breached his duty of care and diligence by misleading and an inadequate disclosure of material information to the board of directors and failure to ensure the statement was incorrect. The board was relying on Mr. Vines to make complete disclosure to all material matters. The court held that, as the director had breach their duties of care and diligence b providing fault statement, thus, he had breach civil penalty provisions. The court decided that, Mr. Vines will have to receive a 3 years disqualification, pay a pecuniary penalty of $100,000 and 22% of the ASIC cost (Price Waterhouse Coopers 2012). ASIC’s position that held from 2004-2012: The position of ASIC held from 2004-2012 in relation to the directors of James Hardie case had not altered. Why would I say that? Below is the details of ASIC’s position in relation to the directors of James Hardie: On he 27th February 2004, the NSW government had authorized Mr. David Jackson to conduct a special commission of Inquiry into James Hardie newly founded foundation-Medical Research and Compensation Foundation (Australian Council of Trade Union 2007). At first instance, it had been found out that, the foundation was in fact had a nearly 1. 5 billion of shortfall, and a media release saying that the MRCF is ‘fully founded’ to meet all the current and future asbestos claims to the Australia Securities Exchange through the approval of the board directors during the directors meeting. Thus, ASIC had alleged that JHIL had made a misleading and deceptive statement. As a result of that, it had raised a principle issue for the board of directors of JHIL, whether or not they had knowingly voted in favor of releasing the ‘misleading’ announcement to ASX (Alcorn 2011). In addition, the sub issues that had been raised are under Section 180(1), was a general counsel can be treated as an officer? The Original Decision: In April 2009, ASIC held that all of the executive, non-executive and company officer had breached their duty of care by approving the media statement to be made in ASX. In particularly, ASIC had alleged that, the company chief executive officer and company secretary or general counsel, Mr. Macdonald and Mr. Shafron had breached the director’s duty of care and diligence under Section 180(1) as they had failed to advice the board to disclose the DOCI information to ASX (Hargovan 2009). Thus the court had imposed penalties on both of them: †¢Mr. Macdonald was disqualified from managing a company for 15 years and a pecuniary penalty of $350,000. According to the Corporation Act 2001, Section 180(1), an officer obtain the power in decision making which affected the whole or substantial part of a business, thus, Mr, Shafron had a positive obligation to advise the board of the disclosure of DOCI. In relation, he was given a disqualification order for 7 years and a pecuniary penalty of $75,000 (Baxt, Finnane and Harris 2012). †¢Mr. Morley had been banned from the management for 5 years and paid a pecuniary penalty of $35,000. †¢However, all of the seven former non-executives directors were disqualified from management for 5 years each and a pecuniary penalty of $30,000. The Appeal: In December 2010, the NSW court of Appeal overturned the finding in relation to liabilities and penalties of the non-executives directors, the CFO and secretary general counsel of James Hardie Industries Ltd as ASIC had failed to prove that the ASX media statement was approved by the board, and as the appellate court had established that some of the directors had acted honestly without any intention to gain benefit from themselves, which is under Section 1317 of the Corporation Act 2001 (Hargovan 2011). Thus, amendment had been made in relation to lessen the liabilities and penalty of the directors and officer can be found in later section (summary of media release). Nevertheless, it’s worth noting that Mr. Shafron, Mr. Morley and ASIC had filled application for special leave to appeal the decision of the Court of Appeal. In May 2011, ASIC had issued media release that stated that they had granted a special leave to appeal the James Hardie decision. ASIC didn’t change their position in relation to the directors of James Hardie and they are still seeking to uphold the finding that the directors of James Hardie had breached their duty by approving the ASX announcement made by the company (ASIC 2011). Media Release’s Summary: This article talk about the ASIC had granted a special leave from the High Court to appeal the decision of the New South Wales Court of Appeal in the James Hardie matter in relation to the former non-executive directors and the former company secretary and general counsel of James Hardie Industries Limited. The ASIC has actually filled his application in the High Court on 14 January 2011. The purpose of ASIC to strive for a special leave is they are seeking clarification about the nature, content and scope of ASIC’s obligation, while the Court of Appeal had concluded that ASIC had breached their duty of fairness, as they failed to call the witness Mr. Rob in the trial judge of James Hardie case (ASIC 2011). The failure to call the witness, Mr.Rob had make a tremendous impact on the decision of the court, as they cannot attest the non-executive directors had voted in favor of the ASX announcement’s draft (Thomas 2011). As a result of that, ASIC is hoping the High Court to uphold the finding if the trial judge that the directors had acted in favor in regards of the ASX announcement made by the company (ASIC 2011). Decision: As a result of that, in August 2009, the NSW Supreme Court had imposed pecuniary penalties on JHIL and all the non-executive officers and executive officers, plus a disqualification order on them for an extensive period.

The Conquest Of Mexico Research Paper Example

The Conquest Of Mexico Paper The Conquest of Mexico The Spaniards, in the conquest of the Mexican people, relied Just as heavily on chance and luck as they did on their on their skills on diplomacy and military prowess. The sicknesses that the Spaniards brought over with them in addition to the political situation that the Mexica had established with their neighbors is what really brought about the downfall of the great Mexican civilizations. In addition to these factors there was also the fact that up to this point in history the Americas have had very little in the way of contact from the outside world and consequently had next to o knowledge of the civilizations across the sea. When they first encountered the Spanish Conquistadors they held the belief that they were from the gods and that Cortez was the reincarnation of one of their gods and as such welcomed them with open arms. When you take into consideration all of the factors mentioned above you will see that the conquest of Aztecs and other Native American civilizations by the Spanish was accomplished by three major factors: diplomacy, military prowess, and no small amount of luck. The first of those factors is the diseases that the Europeans brought across the Atlantic with them. The most notable disease that caused the majority of the deaths among the Native American people was the pestilence of smallpox. We will write a custom essay sample on The Conquest Of Mexico specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on The Conquest Of Mexico specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on The Conquest Of Mexico specifically for you FOR ONLY $16.38 $13.9/page Hire Writer An account of Just how devastating smallpox was among a populace whose immune systems had no prior experience with or any way to combat European diseases can be found in book twelve of the Florentine Codex. Before the Spaniards came to us, first an epidemic broke out, a sickness of pustules. It began in Tepeilhuitl. Large bumps spread on people; some where completely covered. They spread everywhere, on the face, the ead, the chest, etc. [The disease] brought great desolation, a great many died of it. Lockhart, 1993, 190) The account goes on to describe the horrors that the disease had left behind in the lives of those who were lucky enough to survive. Many of the survivors had been left horribly scared or even blinded if they were unlucky enough for the disease to spread into their eyes. The main reason that these diseases had such a devastating effect on the natives and not on the Spaniards is the fact that the natives had very little in the way of domesticated animals. The Europeans had for housands of years been in possession of a great many domesticated animal, such as pigs, horses, chickens, and cows, and it is these animals that are usually the incubators and carriers of a great many deadly diseases. Since the Europeans had been around them for so long their immune systems had adapted to the situation and were able to combat the diseases. The Aztecs had no such advantage. The deadly diseases of Europe were something completely new to them and their immune systems had no way to combat them. The Spaniards had no compunctions about taking advantage of the situation in their conquest of Mexico. Another huge factor that the Spanish had in their favor was the superior weapons that they had at their disposal and huge advantage that the weapons gave them in battle. The Aztec people were severely limited in the type of weapon that they could wield in battle due to the simple fact that their civilization had never discovered the created were made from wood and stone. One such weapon that the majority of the Aztec warriors had in their possession is described in the book titled Victors and Vanquished. Their primary weapon was a kind of wooden sword set with obsidian lades designed for slashing and incapacitating rather than killing an opponent. (Schwartz 2000 1 1) The weapons of the Aztec warriors were all similar to that in that they were designed to incapacitate instead of kill. The entire reason for the Aztecs to be at war was the capture of prisoners that they could sacrifice to their gods. The Spaniards were not like that. Their weapons were designed for one purpose, to kill. Many of those weapons, such as the musket or crossbow, had a much greater range than any of the weapons that the natives could field in battle and they had no answer t all to the power of the Spaniards canons. The one factor that made all of every weapon that the Spaniards had at their disposal superior to any Aztec weapon is the simple fact that they were made of steel. There was one obstacle that the Conquistadors had that would prevent them from overwhelming the Aztecs even with their superior weaponry. That aforementioned obstacle was the fact that the Spanish only numbered in the hundreds while the Aztecs had their entire civilization backing them. The way that they were able to overcome that obstacle was through he art of diplomacy. The constant invasions and taking of prisoners by the Aztecs for their human sacrifices had earned them many enemies among their neighbors. When Spain began its exploration of the new world those very same neighbors saw their chance to finally bring about the destruction of their oppressors. An example of this can be found in a Spanish account of the invasion of Chapultepec. The war was sustained fiercely on both sides, since on our side we had the help of many Tlaxacalan warriors (Aguilar, 1993, 196) The constant warfare and human sacrifice hat the gods of the Aztecs demanded of them had finally helped to bring about the downfall of that great civilization. There was no one thing that brought about the downfall of the Mexican people. It was a conglomeration of events that finally toppled the great civilizations. The sicknesses and plaques that the Europeans brought over with them played no small part. The way in which the natives waged war was also a significant factor. The factor that really broke the back of the Aztecs was the constant need for human sacrifice. In their dealings with their neighbors they had created the oundation that Spaniards used for the negotiating of allies in the conquest of Mexico. In this collision of two previously separate worlds it was the Spanish who came out as the victor and the Aztecs as the vanquished. Aguilar, Francisco De. Eighth Jornada. In Victors and Vanquished, edited by Stuart B. Schwartz, 197-198. Boston: Yale University, 2000 Sahagun, Fray Bernardino De. Florentine Codex In Victors and Vanquished, edited by Stuart B. Schwartz, 190. Boston: Yale University, 2000 Schwartz, Stuart B. Victors and Vanquished. Boston: Yale University, 2000.